PATHOLOGY

Detailed explanation-1: -B-cell development is dependent on the nonlymphoid stromal cells of the bone marrow; stem cells isolated from the bone marrow and grown in culture fail to differentiate into B cells unless bone marrow stromal cells are also present.

Detailed explanation-2: -The B Cell: B cells mature in the bone marrow or in the lymph node. Bone Marrow: Mature B cells express antibodies on their surface, which are specific for a particular antigen.

Detailed explanation-3: -B cells mature in bone marrow and migrate to spleen & lymph nodes for interaction with Ag.

Detailed explanation-4: -Inside the bone marrow, blood stem cells divide and mature to make new blood cells. During this process, the cells become either lymphocytes (a kind of white blood cell) or other blood-forming cells. These other blood-forming cells mature into red blood cells, white blood cells (other than lymphocytes), or platelets.

Detailed explanation-5: -A type of white blood cell that makes antibodies. B cells are part of the immune system and develop from stem cells in the bone marrow. Also called B lymphocyte.