PATHOLOGY

Detailed explanation-1: -Phagocytosis consists in recognition and ingestion of particles larger than 0.5 m into a plasma membrane derived vesicle, known as phagosome. Phagocytes can ingest microbial pathogens, but importantly also apoptotic cells.

Detailed explanation-2: -Macrophages and neutrophils (phagocytes) are the front-line defenders in your body’s immune system. They seek out, ingest, and destroy pathogens and other debris through a process called phagocytosis.

Detailed explanation-3: -To engulf the pathogen, the phagocyte forms a pseudopod that wraps around the pathogen and then pinches it off into a membrane vesicle called a phagosome. Acidification of the phagosome (pH decreases to the range of 4–5) provides an important early antibacterial mechanism.

Detailed explanation-4: -Macrophages, neutrophils, monocytes, dendritic cells, and osteoclasts are among these dedicated cells. These professional phagocytes express several phagocytic receptors that activate signaling pathways resulting in phagocytosis.

Detailed explanation-5: -Several types of cells of the immune system perform phagocytosis, such as neutrophils, macrophages, dendritic cells, and B lymphocytes. The act of phagocytizing pathogenic or foreign particles allows cells of the immune system to know what they are fighting against.