PATHOLOGY MCQ
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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primary line of defense
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secondary line of defense
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Either A or B
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None of the above
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Detailed explanation-1: -A type of immune cell that has granules (small particles) with enzymes that can kill tumor cells or cells infected with a virus. A natural killer cell is a type of white blood cell. Also called NK cell and NK-LGL.
Detailed explanation-2: -Granulocytes. Granulocytes are effector cells that predominate during the early or acute phase of the innate immune response. The main function of these cells is to identify, ingest, and destroy microbial pathogens through receptors, oxidative mechanisms, and enzymes including lysozyme, collagenase, and elastase, etc.
Detailed explanation-3: -Once the decision is made to kill, the NK cell releases cytotoxic granules containing perforin and granzymes, which leads to lysis of the target cell.
Detailed explanation-4: -Interplay of type I interferons (IFNs) and natural killer (NK) cell activation during antitumor response. Type I IFNs either impact on maturation, homeostasis, and activation of NK cells, or indirectly influence NK cells to kill tumor cells via other immune cells or cells of the tumor microenvironment.