PATHOLOGY

Detailed explanation-1: -One of the best-known chemical mediators released from cells during inflammation is histamine, which triggers vasodilation and increases vascular permeability.

Detailed explanation-2: -During acute inflammatory responses, leukocyte-derived mediators such histamine and bradykinin will cause arteriolar dilation thereby increasing blood flow leading to rubor.

Detailed explanation-3: -Injured tissue mast cells release histamine, causing the surrounding blood vessels to dilate and increase in permeability.

Detailed explanation-4: -(b) Histamine increases blood flow to the wound site, and increased vascular permeability allows fluid, proteins, phagocytes, and other immune cells to enter infected tissue. These events result in the swelling and reddening of the injured site, and the increased blood flow to the injured site causes it to feel warm.

Detailed explanation-5: -The affected tissue would release prostaglandins that trigger the inflammatory response, causing blood vessels to leak fluid into the tissues (swelling).