PATHOLOGY

Detailed explanation-1: -The complement product C5a is chemotactic for neutrophils, eosinophils, and macrophages, but not for lymphocytes (288). It is a 74 amino-acid peptide which is found in serum of animals treated with immune complexes or endotoxin.

Detailed explanation-2: -Complement-mediated Chemotaxis The main function of complement is protecting the host from infection/inflammation by recruiting (chemotaxis) and enhancing phagocytosis by innate immunity, finally leading to lysis of the target cells.

Detailed explanation-3: -The small complement fragments C3a, C4a, and C5a act on specific receptors (see Fig. 2.20) to produce local inflammatory responses.