PATHOLOGY MCQ
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Plasma Cell
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Memory B-Cell
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Common B-Cell
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Activated Helper T-Cell
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Detailed explanation-1: -Immunoglobulin heavy-chain gene rearrangement begins in early pro-B cells with D to JH joining. This typically occurs at both alleles of the heavy-chain locus, at which point the cell becomes a late pro-B cell. The cell then proceeds to rearrange a VH gene segment to the DJH sequence.
Detailed explanation-2: -Class switching is the process whereby an activated B cell changes its antibody production from IgM to either IgA, IgG, or IgE depending on the functional requirements.
Detailed explanation-3: -Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals.
Detailed explanation-4: -Ig class switching involves deletions of germline DNA resulting in religation of the VDJ complex to downstream heavy chain C region genes, such as 3, 1 2b, 2a, , and .