PATHOLOGY

Detailed explanation-1: -C5b6789n (the membrane attack complex or MAC) then puts holes in the membrane. In the case of bacteria, MAC can put holes in the outer membrane and possibly the cytoplasmic membrane of the Gram-negative cell wall causing lysis. In the case of enveloped viruses, MAC can damage the viral envelope.

Detailed explanation-2: -(1) Cell lysis caused by a lesion produced by the complement proteins on the antibody-coated cell membrane of target cell. (2) The destruction or lysis of cell with the release of perforins by natural killer cells.

Detailed explanation-3: -The complement membrane attack complex (MAC) is classically known as a cytolytic effector of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or targeted cells, leading to osmolysis.

Detailed explanation-4: -The attack of complement is directed against the lipid moiety of the cell membrane; a single lesion at the site of fixation of complement proteins C5-C9 is responsible for lysis of a cell. There are two hypothetical models for the generation of this membrane lesion.