PATHOLOGY

Detailed explanation-1: -Neutrophils from the blood can be mobilized to sites of infection or inflammation through the process known as the leukocyte adhesion cascade (Ley et al., 2007; Chavakis et al., 2009). Endothelial cells of blood vessels close to the affected site get activated and express adhesion receptors such as E-, and P-selectins.

Detailed explanation-2: -Neutrophils contribute to tissue injury by amplifying the inflammatory response and direct release of toxic effectors. The effectors from neutrophils that may contribute to tissue damage have been discussed in other reviews and will not be discussed in detail here (Kruger et al.