PATHOLOGY MCQ
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Months to Years
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Weeks to Months
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Less than 72 hours
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5-10 Days
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Detailed explanation-1: -Different antibody isotopes are present in human sera (IgM, IgA and IgG). They each have relatively limited half-lives, with a maximum of 17.5–26.0 days for Immunoglobulin G (IgG), which represent about 75% of the antibody isotopes in humans [2], [3], [4].
Detailed explanation-2: -IG is available either as 5% (50 mg/dL) or 10% (100 mg/dL) liquid or as lyophilized preparations. As the name suggests, IVIG is administered intravenously, and the half-life of a typical intravenous immunoglobulin infusion is about 3 to 4 weeks.
Detailed explanation-3: -In humans, the average half-life of IgG in circulation is approximately 3 weeks2 and in mice it is 6–8 days3. However, in FcRn−/−mice the half-life of IgG in circulation is reduced to 1 day4 and the mice cannot maintain IgG homeostasis, resulting in a 70–80% reduction of the total level of IgG.
Detailed explanation-4: -IgG could be detected as early as 4 days after the onset of illness.