PATHOLOGY

Detailed explanation-1: -Because dendritic cells express both class I and class II MHC proteins, they can activate both cytotoxic and helper T cells.

Detailed explanation-2: -In a primary antibody response, naïve helper T cells are activated in a peripheral lymphoid organ by binding to a foreign peptide bound to a class II MHC protein on the surface of a dendritic cell.

Detailed explanation-3: -The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous sources, to CD4(+) T-lymphocytes. MHC class II molecules thereby are critical for the initiation of the antigen-specific immune response.

Detailed explanation-4: -Dendritic cells (DCs) Dendritic cells have the broadest range of antigen presentation and are necessary for activation of naive T cells. DCs present antigen to both helper and cytotoxic T cells.