PATHOLOGY

PATHOLOGY MCQ

IMMUNE RESPONSE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
In the production of monoclonal antibodies, B-cells are fused to tumour cells to make hybridoma cells. What can hybridoma cells do?
A
divide endlessly
B
ingest antigens
C
become memory cells
D
bind to antibodies
Explanation: 

Detailed explanation-1: -Fusion with a tumor cell to make the hybridoma, result in the production of monoclonal antibodies against the specific virus. The hybridoma cells are placed into media that can help them grow and produce the bulk quantities of monoclonal antibodies.

Detailed explanation-2: -Hybridoma technology is one of the most common methods used to produce monoclonal antibodies. In this process, antibody-producing B lymphocytes are isolated from mice after immunizing the mice with specific antigen and are fused with immortal myeloma cell lines to form hybrid cells, called hybridoma cell lines.

Detailed explanation-3: -Hybridoma is a culture of hybrid cells that results from the fusion of B cells and myeloma cells. Hybridoma technology produces hybridomas.

Detailed explanation-4: -Hybridoma technology is a technology of forming hybrid cell lines (called as hybridomas) by fusing an antibody-producing B cell with a myeloma (B cell cancer) cell that is selected for its ability to grow in tissue culture and for an absence of antibody chain synthesis.

Detailed explanation-5: -Hybridoma technology overview Hybridoma cells are generated via fusion between a short-lived antibody-producing B cell and an immortal myeloma cell.

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