PATHOLOGY

Detailed explanation-1: -Mast cells release histamine as well as other vasoactive molecules, which cause urticaria (hives). If the antigen activates mast cells in deeper tissue, this can lead to angioedema. If the response is prolonged, atopic dermatitis or eczema may occur.

Detailed explanation-2: -The granules of mast cells are loaded with histamines. Histamines increase the blood flow to the area and the leakage of fluid and proteins from the blood into the tissue space. Thus, the quick release of histamine produces the redness and swelling associated with inflammation.

Detailed explanation-3: -Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues.

Detailed explanation-4: -Too many mast cells are produced and build up in tissues and body organs, releasing substances such as histamine, leukotrienes and cytokines that cause inflammation and symptoms.