PATHOLOGY

Detailed explanation-1: -Following vasoconstriction, exposed collagen from the damaged surface will encourage platelets to adhere, activate and aggregate to form a platelet plug, sealing off the injured area.

Detailed explanation-2: -Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2.

Detailed explanation-3: -Platelets help prevent bleeding If a blood vessel is damaged, the body sends signals to platelets which cause them to travel to the injured area. Once the platelets arrive at the site, they clump together to form a clot that helps stop bleeding.

Detailed explanation-4: -As blood flow out of damaged blood vessels, blood platelets release a substance called prothrombin which further converted into thrombin.

Detailed explanation-5: -Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis.