PATHOLOGY MCQ
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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when an antigen is displayed by a dendritic cell.
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when a cytotoxic T cell releases cytokines.
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when natural killer (NK) cells come in contact with a tumor cell.
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) in the bone marrow during the self-tolerance test.
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Detailed explanation-1: -In a primary antibody response, naïve helper T cells are activated in a peripheral lymphoid organ by binding to a foreign peptide bound to a class II MHC protein on the surface of a dendritic cell.
Detailed explanation-2: -Mature DCs are characterized by the production of cytokines, such as IL-12, and by the expression of homing receptors, such as CCR7, which directs the migration of DCs into the T-cell regions of secondary lymphoid organs. Together these changes enable DCs to effectively activate naïve T cells.
Detailed explanation-3: -Immune responses are initiated in the T-cell areas of secondary lymphoid organs where naïve T lymphocytes encounter dendritic cells (DCs) that present antigens taken up in peripheral tissues.