PATHOLOGY

Detailed explanation-1: -Macrophages. Macrophages are derived from monocytes and are found in the tissues. They have a major role as a first defence mechanism in phagocytosis of cellular debris, microbes and any other foreign substances.

Detailed explanation-2: -Neutrophils (also called polys, segs, or polymorphonuclear leukocytes) are the most common, making up about 50% to 60% of the total WBCs. Neutrophils are the first to respond to any tissue damage. Their job is to phagocytize bacteria, but they live only 4 days.

Detailed explanation-3: -Monocytes become macrophages There they provide an immediate defense because they can engulf (phagocytose) and digest pathogens before other types of WBCs reach the area.

Detailed explanation-4: -Neutrophils comprise 50% to 70% of circulating leukocytes and represent the body’s initial line of defense. They are involved in the acute inflammatory response to bacterial infection and removal of the bacteria by phagocytosis. They are also the most numerous cells to arrive at the site of injury or infection.