PATHOLOGY

Detailed explanation-1: -During sleep, your immune system releases proteins called cytokines, some of which help promote sleep. Certain cytokines need to increase when you have an infection or inflammation, or when you’re under stress. Sleep deprivation may decrease production of these protective cytokines.

Detailed explanation-2: -Making sure your body has a chance to rest and recover from the day is important for your immune system to function at full strength. When we sleep, our bodies produce a protein called cytokines, which target infection and inflammation, creating an immune response.

Detailed explanation-3: -During the sleep phase, immune cells at early stages of differentiation peak in peripheral blood and lymph nodes. Immune cells migrate. New cells are constantly released from the bone marrow into the circulation.

Detailed explanation-4: -The night-time decrease in cortisol and increase in melatonin is well known to be important for quality sleep, but cytokines such as interleukin (IL)-6 also normally increase at night and induce fatigue.