PATHOLOGY

Detailed explanation-1: -Classical antigen presenting cells (APCs) are dendritic cells (DCs) and B cells (10). To mount an immune response, APCs must first recognize and bind their target. To do so, APCs express antigen-specific surface receptors including pattern recognition receptors (PRRs).

Detailed explanation-2: -Although dendritic cells are important in presenting antigen, particularly to initiate primary immune responses, macrophages are the professional APC type most prominent in inflammatory sites and specialized for clearing necrotic and apoptotic material.

Detailed explanation-3: -An antigen-presenting cell (APC) is an immune cell that detects, engulfs, and informs the adaptive immune response about an infection. When a pathogen is detected, these APCs will phagocytose the pathogen and digest it to form many different fragments of the antigen.

Detailed explanation-4: -Macrophages and dendritic cells function as antigen-presenting cells (APCs). They present peptide antigens derived from digested bacteria on the major histocompatibility complex class II and activate acquired immunity by activating helper T cells.

Detailed explanation-5: -Antigen-presenting cells (APCs) are a heterogeneous group of immune cells that mediate the cellular immune response by processing and presenting antigens for recognition by certain lymphocytes such as T cells. Classical APCs include dendritic cells, macrophages, Langerhans cells and B cells.