PATHOLOGY

Detailed explanation-1: -Injured tissue mast cells release histamine, causing the surrounding blood vessels to dilate and increase in permeability.

Detailed explanation-2: -Mast cells respond to IL-33 released during cell injury by initiating a pro-inflammatory response. During cell injury, for instance induced by mechanical trauma, structural cell types such as epithelial cells release IL-33.

Detailed explanation-3: -Acute inflammation starts after a specific injury that will cause soluble mediators like cytokines, acute phase proteins, and chemokines to promote the migration of neutrophils and macrophages to the area of inflammation.

Detailed explanation-4: -Acute phase response is generated during inflammation. Histamine is a vasoactive amine that plays an important role in the early acute inflammatory response. Histamine is stored in the granules of mast cells, basophils, platelets.