PATHOLOGY

Detailed explanation-1: -Neutrophils. Neutrophils are the most abundant white blood cell in humans and arise from granulocytes. They are also phagocytic in nature, and Metchnikoff called neutrophils the “archetypal phagocyte”. Neutrophils are the first immune cells to be recruited, which can be through the cytokines produced by macrophages.

Detailed explanation-2: -Abstract. Phagocytosis is central to the microbicidal function of neutrophils. Pathogens are initially engulfed into a plasma membrane-derived vacuole, the phagosome, which proceeds to acquire degradative properties by a complex process termed maturation.

Detailed explanation-3: -Phagocytes include neutrophils, macrophages, and dendritic cells (DCs), which have the capacity to engulf and digest relatively large particles on the order of 1–10 µm and even larger. In adults, these cells are generated from hematopoietic stem cells in the bone marrow.

Detailed explanation-4: -There are three main groups of phagocytes: monocytes and macrophages, granulocytes, and dendritic cells, all of which have a slightly different function in the body.

Detailed explanation-5: -A type of white blood cell that is an important part of the immune system and helps the body fight infection. When microorganisms, such as bacteria or viruses, enter the body, neutrophils are one of the first immune cells to respond.