PATHOLOGY MCQ
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What specific part of the antigen receptor is responsible for the variation?
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The variable regions of light chain and heavy chain
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The constant region
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The variable region on the light chain only
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The macrophages
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Explanation:
Detailed explanation-1: -The variable domain is also referred to as the Fv region and is the most important region for binding to antigens. More specifically, variable loops (three each on the light (VL) and heavy (VH) chains) are responsible for binding to the antigen.
Detailed explanation-2: -The primary role of the antibody variable region is to bind to the target antigen. Two important antigen-binding properties are the affinity and the specificity, and engineering these properties has been extensively studied in the past two decades (Table 1).
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