PATHOLOGY MCQ
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Amplifies Cytotoxic T-lymphocyte (CTL) response
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Promotes phagocytosis by macrophage and neutrophils
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Down-regulates the further development of TH2 cells
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Enhances role of mast cells, basophils, and eosinophils
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Detailed explanation-1: -Th1 cells function to activate macrophages and neutrophils; and are critical for host defense against intracellular pathogens such as M. tuberculosis. In support of this, patients with defects in IL-12p40 production, IFN- production, or IFN- receptor signaling have an increased risk of TB.
Detailed explanation-2: -Allergens (or antigens) are presented to T-cells by Antigen-presenting cells (APCs) during the sensitization phase of Type I hypersensitivity.
Detailed explanation-3: -Helper T cells are arguably the most important cells in adaptive immunity, as they are required for almost all adaptive immune responses. They not only help activate B cells to secrete antibodies and macrophages to destroy ingested microbes, but they also help activate cytotoxic T cells to kill infected target cells.
Detailed explanation-4: -Antigen-specific T-cell factors are mediator molecules which are produced by helper and suppressor T cells and which can perform the function of those cells in an antigen-specific manner. They probably play an important part in immunoregulation.