PATHOLOGY

Detailed explanation-1: -Neutrophils are produced inside of the bone marrow (BM) through progressive maturation of hematopoietic progenitors (long-term hematopoietic stem cells [LT-HSCs] to GMPs). Proliferative precursors (NeP and preNeu) differentiate into immature neutrophils and finally into mature neutrophils that are released into blood.

Detailed explanation-2: -These GMPs, under control of the granulocyte colony-stimulating factor (G-CSF) commit to neutrophil generation by turning into myeloblasts, which then follow a maturation process that includes the stages of promyelocyte, myelocyte, metamyelocyte, band cell, and finally a mature neutrophil.

Detailed explanation-3: -The bone marrow is the site of neutrophil production, a process that is regulated by the cytokine granulocyte colony-stimulating factor (G-CSF). Mature neutrophils are continually released into the circulation, with an estimated 1011 neutrophils exiting the bone marrow daily under basal conditions.

Detailed explanation-4: -Once your white blood cells pass basic training in your bone marrow, your immune system sends their troops of mature cells (neutrophils, eosinophils and basophils) to travel through your circulation system and tissues to prepare for invaders that cause illness, infection and disease.