PATHOLOGY MCQ
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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to prevent the recipient’s body from attacking and rejecting the tissue as foreign
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to eliminate the introduction of pathogens into the recipient
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to prevent the recipient’s red blood cells from clotting
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to prevent the formation of antigens in the donated tissue
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Detailed explanation-1: -Prevention. ABO blood typing and HLA (tissue antigen) typing before a transplant helps ensure a close match. You will likely need to take medicine to suppress your immune system for the rest of your life to prevent the tissue from being rejected.
Detailed explanation-2: -Tissue typing ensures that an organ from a donor will be compatible with its recipient. The process starts with identifying the unique human leukocyte antigens (HLAs) for the organ donor and recipient, either from blood or tissue.
Detailed explanation-3: -Immunosupressive drugs. To reduce the risk of transplant rejection, patients are treated with immunosuppressive drugs that will dampen their immune response.
Detailed explanation-4: -Antibodies can result from blood transfusions, pregnancy, infections or even a viral illness. Having one of these events does not mean a person will make antibodies but they could. If a recipient has strong antibodies against a donor’s HLA, the risk of rejection is high and a donor would be declined for that recipient.
Detailed explanation-5: -Transplant Rejection Rejection occurs when the recipient’s immune system recognizes the donor tissue as foreign (non-self), triggering an immune response. The major histocompatibility complex markers MHC I and MHC II, more specifically identified as human leukocyte antigens (HLAs), play a role in transplant rejection.