PATHOLOGY

Detailed explanation-1: -Conclusion. Hyperbaric oxygen did not significantly improve the healing outcome of osteoradionecrosis after surgical removal of necrotic bone as compared to standard care (70% vs. 51%). This effect is not statistically significant due to the fact that the study was underpowered and is therefore prone to type II error.

Detailed explanation-2: -Osteoradionecrosis is a serious side effect of radiation therapy for head and neck cancers. It can take years for symptoms to develop. Treatments include hyperbaric oxygen (HBO) therapy, reconstructive surgery and medical management.

Detailed explanation-3: -Patients should be staged and treated with perioperative hyperbaric treatments and antibiotic therapy, with surgery as needed based on the stage of the osteoradionecrosis. All necrotic bone must be surgically removed.

Detailed explanation-4: -HBOT helps rejuvenate the tissues, gums, and structures of the mouth and jaw by reducing inflammation. In addition, it provides the oxygen necessary to stimulate blood vessel growth to heal the bone and soft tissues in your mouth. Various literature has been published on HBOT and its success in treating ORN.