PATHOLOGY

Detailed explanation-1: -A granuloma is a focal aggregate of immune cells that forms in response to a persistent inflammatory stimulus. It characteristically demonstrates the compact organization of mature macrophages, which may or may not be associated with other inflammatory cell types.

Detailed explanation-2: -Granulomatous inflammation is caused by a variety of conditions including infection, autoimmune, toxic, allergic, drug, and neoplastic conditions. The tissue reaction pattern narrows the pathologic and clinical differential diagnosis and subsequent clinical management.

Detailed explanation-3: -A granuloma is a small area of chronic inflammation, characterized by a collection of macrophages, typically accompanied by helper T-cells.