PATHOLOGY

Detailed explanation-1: -Granulation tissue is considered a contractile organ, characterized histologically by the presence and proliferation of fibroblasts, keratinocytes, endothelial cells, new thin-walled capillaries, and inflammatory cell infiltration of the extracellular matrix.

Detailed explanation-2: -Angiogenesis is the formation of new vessels that developed within the granular tissue in order to supply it with blood and nutrients. As granulation tissue develops, fibroblasts stimulate the production of collagen, which gives tissue strength and structure.

Detailed explanation-3: -Granulation tissue is an extraordinarily vascular complex of fibroblasts and macrophages within a matrix of collagen and fibrin.