PATHOLOGY

Detailed explanation-1: -Neutrophils undergo death through different pathways upon ageing, infection, executing the intruder’s elimination. These include non-lytic apoptosis and other lytic deaths including NETosis, necroptosis and pyroptosis with distinct disintegration of the cellular membrane.

Detailed explanation-2: -Monocytes are phagocytes that can differentiate into macrophages and dendritic cells based on conditions within the body. Macrophages are the cleanup crew for the innate immune system. They remove debris, pathogens, and dead neutrophils after an inflammatory response.

Detailed explanation-3: -The number of circulating neutrophils is tightly regulated. They are cleared in the bone marrow, spleen, and liver. Bone marrow macrophages release G-CSF in response to uptake of returning neutrophils, which then stimulates the release of new neutrophils into the blood flow7.

Detailed explanation-4: -Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms.