PATHOLOGY

Detailed explanation-1: -Definition. Hemostasis is the mechanism that leads to cessation of bleeding from a blood vessel. It is a process that involves multiple interlinked steps. This cascade culminates into the formation of a “plug” that closes up the damaged site of the blood vessel controlling the bleeding.

Detailed explanation-2: -This process is regulated through thromboregulation. Plug formation is activated by a glycoprotein called von Willebrand factor (vWF), which is found in plasma. Platelets play one of major roles in the hemostatic process.

Detailed explanation-3: -Coagulation (or clotting) is the process through which blood changes from a liquid and becomes thicker, like a gel. Coagulation is part of a larger process called hemostasis, which is the way that the body makes bleeding stop when it needs to.

Detailed explanation-4: -There are three steps to the process: vascular spasm, the formation of a platelet plug, and coagulation (blood clotting). Failure of any of these steps will result in hemorrhage-excessive bleeding.

Detailed explanation-5: -Pathology of Hemostasis Proper hemostasis is a function of balance between procoagulant systems (platelets, coagulation cascade) and anticoagulant systems (APC/protein S, fibrinolysis, serpins).