PATHOLOGY

Detailed explanation-1: -Clearance of cellular debris is required to maintain the homeostasis of multicellular organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration and resolution of injury and inflammation.

Detailed explanation-2: -Cellular Phase. The predominant cell of acute inflammation is the neutrophil. They are attracted to the site of injury by the presence of chemotaxins, the mediators released into the blood immediately after the insult.

Detailed explanation-3: -Other functions of the inflammatory response are to prevent the spread of microorganisms or antigen to other areas, to dispose of any cellular debris, and to begin the healing process.

Detailed explanation-4: -What are macrophages? Macrophages are a type of white blood cell that play an important role in the human immune system and carry out various functions including engulfing and digesting microorganisms; clearing out debris and dead cells; and stimulating other cells involved in immune function.

Detailed explanation-5: -The phagocytes clear cell debris by macropinocytosis and release pro-inflammatory cytokines and chemokines for attraction of further macrophages and neutrophils from the blood. In addition, these cytokines promote the activation of stem cells for dead cell replacement.