PATHOLOGY MCQ
INFLAMMATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Kinins
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Prostaglandins
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Leukotriens
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Histamine
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Thromboxane
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Detailed explanation-1: -Prostanoids (prostaglandins, prostacyclin, and thromboxane) are bioactive lipids, members of the eicosanoid class of compounds, derived from arachidonic acid (AA).
Detailed explanation-2: -Cyclooxygenase 1 catalyzes the conversion of arachidonic acid to thromboxane-A2, a potent platelet aggregator (Chapter 36).
Detailed explanation-3: -Arachidonic acid can be metabolized by the enzyme cyclo-oxygenase to produce prostacyclin (PGI2), thromboxane A2 (TXA2) and the stable prostaglandins PGE2, PGF2a and PGD2 [119, 120].
Detailed explanation-4: -The arachidonic acid is then rapidly converted into active metabolites by cyclooxygenases to produce prostaglandins, prostacyclin and thromboxanes, and by lipoxygenase to produce leukotrienes Page et al (2006). The physiological actions of these metabolites have widespread and diverse.