PATHOLOGY

Detailed explanation-1: -Macrophages are important components of the mononuclear phagocyte system, and are critical in inflammation initiation, maintenance, and resolution [75]. During inflammation, macrophages present antigens, undergo phagocytosis, and modulate the immune response by producing cytokines and growth factors.

Detailed explanation-2: -Macrophages, neutrophils, monocytes, dendritic cells, and osteoclasts are among these dedicated cells. These professional phagocytes express several phagocytic receptors that activate signaling pathways resulting in phagocytosis.

Detailed explanation-3: -Neutrophils and macrophages are immune sentinel cells that attack pathogens and repair damage to the host. It is important to regulate their functions for specific purposes.

Detailed explanation-4: -Neutrophils dominate the early stages of inflammation and set the stage for repair of tissue damage by macrophages. These actions are orchestrated by numerous cytokines and the expression of their receptors, which represent a potential means for inhibiting selective aspects of inflammation.

Detailed explanation-5: -Phagocytosis and Inflammation Both macrophages and dendritic cells engulf pathogens and cellular debris through phagocytosis.