PATHOLOGY

PATHOLOGY MCQ

INFLAMMATION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following attracts phagocytes during an inflammatory response?
A
heparin
B
complement proteins
C
histamine
D
platelets
Explanation: 

Detailed explanation-1: -Chemotaxins include bacterial products (e.g. endotoxin), injured tissues, complement proteins (C3a, C4a, C5a) and chemical substances produced by leukocytes (leukotrienes). Chemotaxins both activate phagocytes and attract them to the target site to mediate their effect.

Detailed explanation-2: -The complement receptor 3 (CR3), comprising CD11b, and CD18, is expressed by all monocytes and critical for facilitating phagocytosis of complement-opsonized cells or pathogens (20).

Detailed explanation-3: -The end result of this complement activation or complement fixation cascade is stimulation of phagocytes to clear foreign and damaged material, inflammation to attract additional phagocytes, and activation of the cell-killing membrane attack complex.

There is 1 question to complete.