PATHOLOGY

Detailed explanation-1: -Secretin stimulates the secretion of bicarbonate-rich pancreatic fluid. [11] Secretin enters the intestinal lumen and stimulates bicarbonate secretion, ultimately neutralizing gastric H+, which plays an essential role in fat digestion by creating a more neutral (pH 6 to 8) environment.

Detailed explanation-2: -Regulation of pancreatic bicarbonate secretion Secretin enters the blood stream or intestinal lumen and stimulates bicarbonate secretion (by interacting with pancreatic ductal cells), which neutralizes the pH of the gastric chyme upon entering the small intestine (83, 84).

Detailed explanation-3: -The principal target for secretin is the pancreas, which responds by secreting a bicarbonate-rich fluid, which flows into the first part of the intestine through the pancreatic duct.

Detailed explanation-4: -Cholecystokinin (CCK), which is released from the duodenal mucosal enteroendocrine cells after chemical stimulation by food, activates pancreatic enzyme secretion by stimulating vagal afferents.