PATHOLOGY

Detailed explanation-1: -When self-tolerance is lost, the immune system is deployed against one or more of the body’s own molecules. The civil war directed against autologous tissue resulting from the loss of self-tolerance is the hallmark of the autoimmune diseases (AIDx).

Detailed explanation-2: -Autoimmune diseases are a group of >80 chronic, relapsing, and sometimes lethal diseases, characterized by a defective immune system resulting in the loss of tolerance to self-antigens and over-expression of autoantibodies.

Detailed explanation-3: -If immunological self-tolerance is lost, the body develops an autoimmunity against its own tissues and cells, which become the source of the autoimmune disease. Self-tolerance plays a key role in the prevention and treatment of immune disorder diseases, especially autoimmune diseases.