PATHOLOGY

Detailed explanation-1: -In the case of T cells, development is compartmentalized, with different types of stromal cells in the thymic cortex and medulla. Most steps in T-cell differentiation occur in the cortex of the thymus. The thymic medulla contains mainly mature T cells.

Detailed explanation-2: -The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 / T cells, / T cells, NKT cells, Treg, and IEL all develop in and must leave the thymus to provide their functions elsewhere in the body.

Detailed explanation-3: -The NK/T precursors migrate to the thymus, where thymocyte development proceeds in three multipartite phases: the DN phase (neither CD4 nor CD8 appears on the thymocyte surface), the DP phase (both CD4 and CD8 are present), and the SP phase (either CD4 or CD8 is present on the surface of a mature T cell).