PATHOLOGY

Detailed explanation-1: -Leydig cells are the primary source of testosterone or androgens in males. This physiology allows them to play a crucial role in many vital physiological processes in males, including sperm production or spermatogenesis, controlling sexual development, and maintaining secondary sexual characteristics and behaviors.

Detailed explanation-2: -Leydig cells produce testosterone in the testes under the pulsatile control of pituitary luteinizing hormone (LH). cAMP is the intracellular messenger for LH action on steroidogenesis, and pharmacological evidence indicates that the response to LH can be modulated by cyclic nucleotide phosphodiesterases (PDEs).

Detailed explanation-3: -Testosterone and other androgens are made by Leydig cells. The germ cells are fed by the Sertoli cells. They create a variety of proteins, including enzymes, hormones, androgen binding proteins, and inhibin. Sertoli cells do not produce testosterone.

Detailed explanation-4: -Sertoli and Leydig cells represent two major somatic cells that are characteristic of testicular architecture and function. Sertoli cells, which provide the anchor for germ cell development, are restricted to the tubular compartment of the testis, whereas Leydig cells are present in the intertubular/interstitial space.