PATHOLOGY

Detailed explanation-1: -Fetal Leydig cells produce the high levels of testosterone that are required for the differentiation of the male genitalia and for brain masculinization.

Detailed explanation-2: -Leydig cells produce testosterone in the testes under the pulsatile control of pituitary luteinizing hormone (LH). cAMP is the intracellular messenger for LH action on steroidogenesis, and pharmacological evidence indicates that the response to LH can be modulated by cyclic nucleotide phosphodiesterases (PDEs).

Detailed explanation-3: -It is secreted by the interstitial cells of Leydig in the testes and by the adrenal glands in both males and females.

Detailed explanation-4: -Testosterone is produced by the gonads (by the Leydig cells in testes in men and by the ovaries in women), although small quantities are also produced by the adrenal glands in both sexes.