PATHOLOGY

Detailed explanation-1: -Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis. Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is affected by a universal machinery that includes SNARE (for “soluble NSF-attachment protein receptor”) and SM (for “Sec1/Munc18-like”) proteins.

Detailed explanation-2: -Neurotransmitter is stored inside small sacs called synaptic vesicles, and is released into the synaptic cleft of the synapse when a vesicle fuses with the cell membrane. This process, which is known as exocytosis, can release neurotransmitter in less than a millisecond.

Detailed explanation-3: -At nerve terminals, neurotransmitter release is mediated by exocytosis of synaptic vesicles at active zone. After exocytosis, vesicular components are efficiently retrieved by endocytosis.