PATHOLOGY

Detailed explanation-1: -Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers.

Detailed explanation-2: -Myelinated (A-fiber) nociceptors mediate the sharp, pricking pain associated with application of intense heat or sharp objects. The enhanced pain sensation at the site of skin injury (primary hyperalgesia) is thought to result from an enhanced responsiveness (sensitization) of cutaneous nociceptors.

Detailed explanation-3: -The somatosensory receptors can be activated by these different stimuli that act on mechanoreceptors (including proprioception), nociceptors, thermoreceptors and chemoreceptors.