PATHOLOGY

Detailed explanation-1: -Where is the substantia nigra located? The SN is in your midbrain. As the name suggests, this section of your brain is at the center of your brain.

Detailed explanation-2: -The substantia nigra (SN) is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. It is one of the brainstem nuclei and part of the extrapyramidal system.

Detailed explanation-3: -The substantia nigra, located in the ventral mesencephalon, is one of the five nuclei that constitute the basal ganglia circuit, which controls voluntary movements. It is divided into the pars compacta and the pars reticulata, which mainly contain dopaminergic and GABAergic cells respectively.

Detailed explanation-4: -The basal ganglia are situated at the base of the forebrain and top of the midbrain. Basal ganglia are strongly interconnected with the cerebral cortex, thalamus, and brainstem, as well as several other brain areas.