PATHOLOGY

Detailed explanation-1: -Studies have demonstrated that TRPM8 channels are the principal cold sensor in cold-sensing afferent neurons; cold temperatures open TRPM8 channels to cause membrane depolarization and AP firing in the cold-sensing afferent neurons (McKemy et al., 2002, Peier et al., 2002).

Detailed explanation-2: -If the temperature is too low, the channels will not open, and electrical pulses cannot travel down the nerve. If the temperature is too high, the ion channels and nerve membranes come apart.