PATHOLOGY

Detailed explanation-1: -This lack of pain awareness often leads to an accumulation of wounds, bruises, broken bones, and other health issues that may go undetected. Young children with congenital insensitivity to pain may have mouth or finger wounds due to repeated self-biting and may also experience multiple burn-related injuries.

Detailed explanation-2: -It is inherited in an autosomal recessive pattern. Congenital insensitivity to pain is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which connects the brain and spinal cord to muscles and to cells that detect sensations such as touch, smell, and pain.

Detailed explanation-3: -Congenital insensitivity to pain with anhidrosis. It’s characterized by the inability to feel physical pain and the inability to sweat from birth. People with CIPA often have recurrent fevers, an inability to perceive temperature extremes, developmental delays, behavioral problems, and hypotonia.