PATHOLOGY

Detailed explanation-1: -An action potential is a rapid sequence of changes in the voltage across a membrane. The membrane voltage, or potential, is determined at any time by the relative ratio of ions, extracellular to intracellular, and the permeability of each ion.

Detailed explanation-2: -Action potential is a brief reversal of membrane potential where the membrane potential changes from-70mV to +30mV. When the membrane potential of the axon hillock of a neuron reaches threshold, a rapid change in membrane potential occurs in the form of an action potential.

Detailed explanation-3: -The membrane potential represents a balance among the equilibrium potentials of the ions to which the membrane is permeable. The greater the conductance of an ion, the more that ion will influence the membrane potential of the cell.

Detailed explanation-4: -Propagation. The action potential generated at the axon hillock propagates as a wave along the axon. The currents flowing inwards at a point on the axon during an action potential spread out along the axon, and depolarize the adjacent sections of its membrane.