PATHOLOGY

Detailed explanation-1: -Microglia are the primary immune cells of the central nervous system, similar to peripheral macrophages. They respond to pathogens and injury by changing morphology and migrating to the site of infection/injury, where they destroy pathogens and remove damaged cells.

Detailed explanation-2: -As the primary resident phagocytes of the CNS, microglia play an important role in preventing the accumulation of this toxic protein through both phagocytosis and the production of degrading intra-and extracellular enzymes (149).

Detailed explanation-3: -There are three types of glial cells in the mature central nervous system: astrocytes, oligodendrocytes, and microglial cells (Figure 1.4A-C).