PATHOLOGY

Detailed explanation-1: -Mechanosensitive channels, mechanosensitive ion channels or stretch-gated ion channels are membrane proteins capable of responding to mechanical stress over a wide dynamic range of external mechanical stimuli.

Detailed explanation-2: -Mechanically activated ion channels can respond to a diverse range of physical forces such as vibration, stretch, or sound waves (Delmas et al., 2011).

Detailed explanation-3: -Mechano-gated channels are a subtype of gated ion channels engaged in converting mechanical stimuli to chemical or electrical signals thereby modulating sensation. To date, a few families of mechano-gated channels (DEG/ENaC, TRPN, K2P, TMC and Piezo) have been identified in eukaryotes.