PATHOLOGY

Detailed explanation-1: -In your pancreas, somatostatin prevents (inhibits) the release of pancreatic hormones, including insulin, glucagon and gastrin, and pancreatic enzymes that aid in digestion. In your gastrointestinal (GI) tract, somatostatin reduces gastric secretion, which is stimulated by the act of eating.

Detailed explanation-2: -These data indicate that an increase in insulin per se suppresses glucagon secretion and a decrease in insulin per se, in concert with a low glucose concentration, stimulates glucagon secretion.

Detailed explanation-3: -Glucagon can directly stimulate somatostatin secretion, independently of insulin. Studies have demonstrated that glucagon plays a role in stimulating insulin secretion by a direct effect on glucagon and GLP-1 receptors expressed on the beta cells [12, 14, 17].

Detailed explanation-4: -These results show that somatostatin lowers blood glucose concentrations as a secondary effect of inhibition of glucagon secretion.