PATHOLOGY MCQ
PANCREAS
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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cholecystokinin
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secretin
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enterokinase
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lipase
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Detailed explanation-1: -Mold kinase transforms trypsinogen to trypsin only in an acid medium. It differs thus from enterokinase and trypsin which activate trypsinogen best in a slightly alkaline medium.
Detailed explanation-2: -Pro-enzyme trypsinogen occurs in two major isoenzymes in humans (trypsinogen 1, i.e. cationic trypsinogen form, and trypsinogen 2, i.e. anionic trypsinogen form), which are activated to trypsin by enterokinase (EK) in the gut for digestion.
Detailed explanation-3: -Trypsinogen is converted to trypsin through the action of an enzyme secreted in the duodenum called Enteropeptidase. This enzymes activates trypsin by cleaving off a portion of trypsinogen, resulting in active trypsin. Therefore, the correct answer is C) Proteolysis of trypsinogen forms trypsin.