PATHOLOGY

Detailed explanation-1: -The Pacinian corpuscle is a pressure receptor that responds to high-frequency vibratory stimuli. The corpuscle is fluid-filled and essentially incompressible. It consists of a single nerve fibre, the terminal region of which is enclosed in a multilaminated connective tissue capsule.

Detailed explanation-2: -The sensory fibers that respond to stimuli that damage tissue and can cause pain are called nociceptors.

Detailed explanation-3: -Transient receptor potential channels (TRP channels) are believed to play a role in many species in sensation of hot, cold, and pain. Mammals have at least two types of sensor: those that detect heat (i.e., temperatures above body temperature) and those that detect cold (i.e. temperatures below body temperature).

Detailed explanation-4: -Pacinian corpuscles respond to deep pressure, Meissner’s corpuscles respond to light touch and pain receptors respond to many stimuli-extreme temperature, forceful touch, acids, etc. When you extend the temperature beyond the level of cool and warm, the pain receptors in the skin are activated.