PATHOLOGY

Detailed explanation-1: -The oldest epidermal cells in the epidermis are found in the stratum basale .

Detailed explanation-2: -stratum corneum: the outermost layer of skin, made up of layers of very resilient and specialized skin cells and keratin.

Detailed explanation-3: -The stratum corneum is the outermost layer of the epidermis, and is made up of 10 to 30 thin layers of continually shedding, dead keratinocytes. The stratum corneum is also known as the “horny layer, ‘’ because its cells are toughened like an animal’s horn.

Detailed explanation-4: -The stratum corneum consists of flattened, nonviable corneocytes filled with hydrophilic keratin proteins and separated by hydrophobic lamellar lipids, providing an effective barrier to the absorption of most drugs and toxins.