PATHOLOGY

Detailed explanation-1: -Keratinocytes are cells that make up over 90% of the epidermis or the outer layer of the skin. They produce an secrete a protein called “keratin” which is also called an intermediate filament protein, that holds the skin cells and layers together.

Detailed explanation-2: -As the most dominant cell type constituting the epidermis, keratinocytes play multiple roles essential for skin repair. They are the executors of the re-epithelialization process, whereby keratinocytes migrate, proliferate, and differentiate to restore the epidermal barrier.

Detailed explanation-3: -Definition and Location Keratinocytes represent the major cell type of the epidermis, the outermost of the layers of the skin, making up about 90 percent of the cells there. They originate in the deepest layer of the epidermis, the stratum basale and move up to the final barrier layer of the skin, the stratum corneum.

Detailed explanation-4: -Keratinocytes are the predominant cell type of epidermis and originate in the basal layer, produce keratin, and are responsible for the formation of the epidermal water barrier by making and secreting lipids.